New SuperFi-Cas9 Increases Fidelity Without Sacrificing Speed - GEN - Genetic Engineering ...

A redesigned Cas9 is thousands of times less likely to target the wrong stretch of DNA while remaining just as efficient as the original version.

CRISPRCas9 has limitations. One of the most concerning, in regards to using genome editing for therapeutic applications for humans, is off-target DNA cleavage. Although some Cas9 variants have been d… [+3856 chars]

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