Targeting Xist with compounds that disrupt RNA structure and X inactivation - Nature.com

3/30/2022 12:00:00 AM3 years 1 month ago

A molecule identified in a screen for compounds that bind the non-coding mouse RNA Xist blocks Xist-dependent X-chromosome inactivation, demonstrating the utility of this approach for identifying drugs that target RNA.

Consortium, E. P. et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature447, 799816 (2007). Article ADS Google Scholar full article...

Targeting Xist with compounds that disrupt RNA structure and X inactivation - Nature.com

A molecule identified in a screen for compounds that bind the non-coding mouse RNA Xist blocks Xist-dependent X-chromosome inactivation, demonstrating the utility of this approach for identifying drugs that&nbsp;target RNA.

A molecule identified in a screen for compounds that bind the non-coding mouse RNA Xist blocks Xist-dependent X-chromosome inactivation, demonstrating the utility of this approach for identifying drugs that target RNA.