Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking - Nature.com

Single-cell whole-genome sequencing of proximal bronchial basal cells shows that somatic mutations accumulate with age and at a higher level in smokers compared to never-smokers. Mutation frequencies increased with smoking dose but then plateaued, suggesting …

Flanders, W. D. et al. Lung cancer mortality in relation to age, duration of smoking, and daily cigarette consumption. Cancer Res.63, 65566562 (2003). CAS  PubMed  Google Scholar 

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