Fundamental immune–oncogenicity trade-offs define driver mutation fitness - Nature.com

A mathematical framework to estimate the fitness of cancer driver mutations by integrating mutational bias, oncogenicity and immunogenicity finds fundamental trade-offs in cancer evolution.

The distribution of mutations in cancer is highly non-uniform. Mutations in oncogenes and tumour suppressors are enriched across cancers, and specific sites known as hotspots are more frequently muta… [+28492 chars]

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