ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in Rheumatoid Arthritis - EurekAlert

Adenosine triphosphate (ATP) secreted from sensory neuron-interneuron crosstalk is key to the spreading of inflammation across joints, acting as a neurotransmitter and inflammation enhancer.

image: The inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn triggers an increase in … [+4423 chars]

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