CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis - Nature.com

Combined CRISPRi chemical genetics and comparative genomics reveal Mycobacterium tuberculosis drug resistance mechanisms and a potential opportunity to repurpose clarithromycin to treat tuberculosis due to inactivation of the whiB7 resistance factor in an ent…

Defining genetic determinants of drug potency with CRISPRi To define genes that influence drug potency in Mtb, we performed 90 CRISPRi screens across nine drugs in H37Rv Mtb. These screens used a ge… [+29891 chars]

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