The road to fully programmable protein catalysis - Nature.com


6/1/2022 12:00:00 AM2 years 11 months ago

Recent progress in computational enzyme design, active site engineering and directed evolution are reviewed, highlighting methodological innovations needed to deliver improved designer biocatalysts.

  • Savile, C. K. et al. Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture. Science329, 305309 (2010). ADS  CAS  PubMed  Article  Google Schol… [+25245 chars]

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