Sirt6-mediated epigenetic modification of DNA accessibility is essential for Pou2f3-induced thymic tuft cell development | Communications Biology - Nature.com

Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. Single-cell ATAC-seq of medullary TECs suggests that Sirt6-mediated epigenetic regulation may regulate the development of thymic tuft cells from these TECs.

Single-cell chromatin accessibility profiling of mouse mTECs The single-cell assay for transposase-accessible chromatin with sequencing (scATAC-seq) method, which identifies active DNA regulatory el… [+33527 chars]

full article...