Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes | Communications Biology - Nature.com

High-throughput screening of 120,000 compounds followed by counter-screening and validation assays reveals candidate antimalarial drugs that kill Plasmodium falciparum sexual and asexual blood stages blocking parasite transmission through mosquito.

Ten years ago two milestone HTS campaigns populated the antimalarial drug discovery pipeline of hits against asexual blood stages18, establishing a notable portion of the current antimalarial drug di… [+10789 chars]

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