Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections | Communications Biology - Nature.com

Matthew Parker et al. use the ARTIC network tiled amplicon PCR and Oxford Nanopore sequencing of thousands of SARS-CoV-2 samples to detect subgenomic RNA changes in the B.1.1.7 lineage endemic in the UK in late 2020/early 2021. They discovered higher subgenom…

Subgenomic RNA abundance in B.1.1.7 compared to other lineages We stratified sgRNA abundance by lineage in 4400 SARS-CoV-2 sequences that reached our previously defined quality control thresholds (&… [+17190 chars]

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