Biosynthesis of strychnine - Nature.com

The biosynthetic pathway of strychnine, brucine and diaboline is described, and the biosynthesis of these complex, pharmacologically active compounds has been successfully recapitulated in Nicotiana benthamiana from an upstream intermediate.

Strychninea complex monoterpene indole alkaloidwas isolated in 1818 from the seeds of Strychnos nux-vomica (poison nuts)5, which were used in traditional medicine in China and South Asia. Currently, … [+24263 chars]

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