Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks - Nature.com

Pooled loss-of-function CRISPR screens in primary human T cells identify upstream regulators of IL2RA, IL-2 and CTLA4. Individual knockouts of 24 regulators of IL2RA define a central network enriched for genes associated with immune-mediated diseases.

Buniello, A. et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res.47, D1005D1012 (2019). CAS  PubMed  … [+18168 chars]

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