SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model - Nature.com

Molnupiravir was the first orally available SARS-CoV-2 antiviral approved for outpatient use against SARS-CoV-2, but its efficacy against variants of concern, especially delta, was questioned. Here the authors evaluate molnupiravir against variant of concern …

For quantitative comparison of molnupiravir activity against VOC alpha, beta, gamma, delta, and omicron in cultured cells, we determined half-maximal antiviral concentrations (EC50s) on VeroE6 cells … [+22267 chars]

full article...