Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance - Nature.com

Acquired resistance to cetuximab can be mediated by generation of mutations in the EGFR ectodomain. Here the authors report a structure-guided and phage-assisted evolution approach for cetuximab evolution to reverse resistance without altering the binding epi…

Many acquired EGFR mutations block cetuximab and/or panitumumab binding and confer drug resistance Recent studies have shown that a number of EGFR ECD mutations may be acquired in patients with meta… [+31927 chars]

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