Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma | Communications Biology - Nature.com

In human and murine GBM cells, and wildtype murine astrocytes, radiation induces senescence. Overall, female cells are more sensitive to radiation and to p21-induced senescence. This may contribute to the female survival advantage in GBM.

Unique molecular pathways contribute to radiation response in male and female primary human GBM cell lines Female GBM patients exhibit significantly longer median survival than male patients5,15; co… [+46521 chars]

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