The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis | Communications Biology - Nature.com

The kinetochore protein Mis6 (CENP-I) plays an important role in CENP-A maintenance during mitosis in fission yeast and blocks the indiscriminate transcription of non-coding RNAs at the core centromere to retain CENP-A during mitosis.

Cnp1 is not recruited to centromeres during metaphase The Mis18 complex and Scm3 (HJURP) are loading factors for Cnp1 (CENP-A) conserved in fission yeast and higher eukaryotes, such as chickens and … [+26123 chars]

full article...