SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization - Nature.com

SARS-CoV-2 variants have accumulated multiple defining mutations within their spike glycoproteins. Here, the authors report a structural basis for broad neutralization of several variants by a heavy chain antibody fragment and provide a mutational analysis fo…

Plasmids and cloning SARS-CoV-2 S protein Alpha, Beta, Gamma, and Epsilon genes were synthesized and inserted into pcDNA3.1 (GeneArt Gene Synthesis, Thermo Fisher Scientific). Alpha, Beta, Gamma, Ep… [+16821 chars]

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