GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice - Nature.com

A conjugate drug consisting of GLP-1 receptor agonist and the PPARɑ/ɣ dual-agonist tesaglitazar is shown to have superior anti-diabetic effects than monotherapy.

Compound synthesis Peptidyl resin with modified GLP-1 backbone sequence of Boc-His(Trt)-aib-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-Val-Ser(tBu)-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)-Glu(Ot… [+18954 chars]

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