Selective uptake of a DNA gyrase poison kills Mycobacterium tuberculosis - Nature.com

8/22/2022 12:00:00 AM2 years 8 months ago

Photorhabdus noenieputensis (a gut microbiota symbiont of nematodes) produces a macrocyclic antibiotic, evybactin, that selectively kills Mycobacterium tuberculosis (Mtb). The Mtb membrane transporter BacA imports evybactin into the cell, where it binds to DN…

Kinsella, R. L. et al. Perspectives and advances in the understanding of tuberculosis. Annu. Rev. Pathol.16, 377408 (2021). This is a Review of tuberculosis. CAS Article Google Scholar full article...