Pancreatic Development Disrupted by Mutations in the Dark Genome - Genetic Engineering & Biotechnology News

Mutations in the enhancer element EnhP responsible for malformations in the pancreas and diabetes in newborns, indicate disruptions in nonprotein coding DNA elements can cause inherited diseases. The researchers showed that mice lacking both copies of EnhP we…

Nearly 98% of the human genome does not encode proteins but comprises noncoding sequencesthe “dark genome”such as regulatory sequences that control gene transcription (enhancer elements). Thousands o… [+3848 chars]

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