Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape - Nature.com

The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F substitutions …

Gene construction The Omicron spike ectodomain protein (Novoprotein, Cat: DRA193) with furin cleavage site mutants (R682G, R683S, and R685S), 2P mutants (K986P and V987P), a C-terminal T4 fibritin t… [+16653 chars]

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