[= ] . , , ? . /= , . . , . . “ . , . 2 ” . , ‘ ’ . . . D . 3 . … 1 ? . , . . “ . . ” . . , . . . 1 . () . hongsi@sporbiz.co.kr © () PICK
[ ] . , . 11 (NTCP) NTCP- 3 30() . , NTCP(Sodium taurocholate cotransporting polypeptide) B , D . NTCP B (HBV) D (HDV) . NTCP . (Glyco-protein) . NTCP , (Cryo-EM) NTCP . , . NTCP NTCP NTCP , , .
: 100-745 124 (1 25) l : (02) 2000-9000 // . Copyright © All rights reserved.
| . ‘ ’ . , , , , . . . , . ‘ ’ . ! . . , . . , . , , . - , , , , . , . , , , , . , , , , , . , . , , . . , , . . . . . 1 2 . 1, 2 , . 1 2 , 2 . 1 1 2 . 2 , , . 2 , , .… [+148 chars]
[= ] . , , ? . /= , . . , . . “ . , . 2 ” . , ‘ ’ . . . D . 3 . … 1 ? . , . . “ . . ” . . , . . . 1 . () . hongsi@sporbiz.co.kr © () PICK
. D E. ' 8 2 (2020) ' , D, E . D E . D E D , , ··, . , , , . E . , , . D E , D·E . , 1 D 3.1 . 1 D 10(5~15) , ( ) 31.4% . . D 35.1%, 27.7% . E , 1 6.5 mg -TE. 7.2 mg -TE, 5.7 mg -TE . 56.8%, 63.8… [+109 chars]
. 3 , . . , . 50 = . . . . 50 10 2 . · . 2 3 , 2 . 1 15%, 2 25%, 5 45% . 1 50% . . . , . . , . . = , . . (BMI 18.5 ) , · , , , . . . D . . 800, 1000, 1500 . 500 . · 300 , . D 800IU . 10… [+31 chars]
, . [=] (19) . (APA) , 10 9(87%) . 8% . (51%) . APA 19 . . . . , , . , , . 10 () . . , . 10 . , , . , . . . . . , . , . . , . . . . 5 11 . , 7 . . . . . , , . . . . . . 20… [+62 chars]
‘ ’(BBB Blood Brain Barrier) . 7 4 ‘ BBB’(hiMCS-BBB) . () , . (Molecular Pharmaceutics) . ( ) . (astrocyte) (pericyte) . . . . . 3 hiMCS-BBB (HBMEC/ci18, HASTR/ci35, HBPC/ci37) 3 ‘ (h… [+253 chars]
. , . . .. . . , , , ·, , . 7 1 . , . . , , . . (·) A .
. = [ ] '' . 5 45% . . '' 3 . . 5% . . . . . 50 10 2 . , 2 3 2 3 . 2 . 1 15%, 2 25%, 5 45% . 1 50% . . . . . ( 18.5 ) , , , . . . . . . . D . . 800… [+92 chars]
, , (Listeria) . , , , . , . ' (Listeria monocytogenes)' , . , . , . . , , (listeric meningitis) 70% , 50%, 80% . , , . , . 2~3( 70) . , , . , , , 15~70% .… [+181 chars]
